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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K1 All Species: 44.85
Human Site: S194 Identified Species: 75.9
UniProt: Q02750 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02750 NP_002746.1 393 43439 S194 M H R D V K P S N I L V N S R
Chimpanzee Pan troglodytes Q9XT09 393 43428 S194 M H R D V Q P S N I L V N S R
Rhesus Macaque Macaca mulatta XP_001110225 393 43444 S194 M H R D V K P S N I L V N S R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P31938 393 43456 S194 M H R D V K P S N I L V N S R
Rat Rattus norvegicus Q01986 393 43447 S194 M H R D V K P S N I L V N S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511248 391 43070 S210 M H R D V K P S N I L V N S R
Chicken Gallus gallus Q90891 398 44059 S196 M H R D V K P S N I L V N S R
Frog Xenopus laevis Q05116 395 43724 S194 M H R D V K P S N I L V N S R
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 K184 I P E D I L G K I T V S I V K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24324 396 43851 S213 I H R D V K P S N I L V N S S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10664 387 42776 S199 L H R D V K P S N M L V N S N
Sea Urchin Strong. purpuratus XP_781505 412 45737 S215 M H R D V K P S N I L V N S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S7U9 363 39830 R191 H D R H I I H R D L K P S N L
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 N490 H R D V K P T N I L C S A N Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 99.7 N.A. N.A. 98.9 99.2 N.A. 73 81.6 91.9 33.3 N.A. 62.3 N.A. 52.4 64.8
Protein Similarity: 100 99.2 100 N.A. N.A. 99.4 99.7 N.A. 77.8 88.9 96.1 51.4 N.A. 77.7 N.A. 69.2 75.7
P-Site Identity: 100 93.3 100 N.A. N.A. 100 100 N.A. 100 100 100 6.6 N.A. 86.6 N.A. 80 100
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 100 100 33.3 N.A. 93.3 N.A. 93.3 100
Percent
Protein Identity: N.A. N.A. N.A. 34.3 20.2 N.A.
Protein Similarity: N.A. N.A. N.A. 51.4 33.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 8 8 86 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 15 79 0 8 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 15 0 0 0 15 8 0 0 15 72 0 0 8 0 0 % I
% Lys: 0 0 0 0 8 72 0 8 0 0 8 0 0 0 8 % K
% Leu: 8 0 0 0 0 8 0 0 0 15 79 0 0 0 8 % L
% Met: 65 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 8 79 0 0 0 79 15 8 % N
% Pro: 0 8 0 0 0 8 79 0 0 0 0 8 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % Q
% Arg: 0 8 86 0 0 0 0 8 0 0 0 0 0 0 65 % R
% Ser: 0 0 0 0 0 0 0 79 0 0 0 15 8 79 8 % S
% Thr: 0 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % T
% Val: 0 0 0 8 79 0 0 0 0 0 8 79 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _